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fibril

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Exemple din articole cu fibril

• In this review we describe predominantly in vitro studies of oligomerization and amyloid fibril formation by human stefins A and B.
• Background Amyloid fibril formation is the hallmark of many human diseases, including Alzheimer's disease, type II diabetes and amyloidosis.
• In summary, neprilysin decreases islet amyloid deposition by inhibiting hIAPP fibril formation, rather than degrading hIAPP.
• The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens.
• We investigate the thermodynamical and magnetic properties of a "dark-cored" fibril seen in the chromospheric Ca II IR line at 854.
• At a fixed concentration of monomeric beta(2)-m, the apparent rate of fibril elongation increased with an increase in the concentration of seeds and then saturated, suggesting the accumulation of a rate-limiting intermediate.
• In addition to the expected relationship between fragmentation and the ability to seed, we show a striking finding that fibril length correlates with the ability to disrupt membranes and to reduce cell viability.
• Knowledge of the fibril structure is essential to understanding the molecular mechanism of amyloid formation and could lead to the development of agents to inhibit or reverse the process.
• The team, led by Chris Dobson and Mark Welland from the University of Cambridge, UK, came up with a new approach to solving the set of 'master equations' that describe the complex kinetics of fibril formation.
• Enhanced amyloid fibril formation of insulin in contact with catalytic hydrophobic surfaces Engineering Academic Projects(Biological Engineering)
• Here we examine one often-proposed fibril formation mechanism, nucleated polymerization with off-pathway aggregation.
• Abstract The relationship between collagen fibril morphology and the functional behavior of tendon tissue has been investigated in numerous experimental studies.

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