constitutive
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- Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo .
- Features of constitutive gr/gr deletion in a Japanese population.
- Here we show that JAK2V617F requires an intact SH2 domain for constitutive activation of downstream signaling pathways.
- These animals displayed constitutive JAK2 activation and autonomous erythroid progenitor cell growth.
- Overall, our results reveal a novel cooperative role of Brg-1 and Sp1 in mediating the constitutive and fenretinide-induced expression of SPARC, and provide new insights for the understanding of the anti-cancer effects of fenretinide.
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